Bio-Data Mining

Data mining is the nontrivial extraction of implicit, previously unknown, and potentially useful information from large volume of actual data. BISL is developing various data mining techniques based on convolutional neural networks, recursive neural networks, support vector machine, and others, to solve prospective biomedical applications in precision medicine, drug discovery, and functional food development.

•In silico profiling of systemic effects of drugs to predict unexpected interactions, Scientific Reports, 2018

•Topological motifs populates complex networks through grouped attachments, Scientific Reports, 2018

•Deconvoluting essential gene signatures for cancer growth from genomic expressions in compound-treated cells, Bioinformatics, 2018

•Network-based classification of breast cancer metastasis, Molecular Systems Biology, 2007

•Inferring pathway activity toward precise disease classification, PLoS Computational Biology, 2009

Systems Bioinformatics

BISL has been developing a knowledge-based virtual human system, CODA, which can explore functional effects of medicinal compounds in the systemic level. CODA integrates three types of physiological knowledge from public structured databases, literatures, and in-house experiments into a unified format of physiological interactions. CODA can predict possible phenotypic effects of medicinal compounds in the systemic level. CODA can also predict possible effect paths encompassing molecular, functional, and disease level interactions.

•CODA: Integrating multi-level context-oriented directed associations for drug effects analysis, Scientific Reports, 2017

•HIDEEP: a systems approach to predict hormone impacts on drug efficacy based on effect paths, Scientific Reports, 2017

•In silico profiling of systemic effects of drugs to predict unexpected interactions, Scientific Reports, 2018

•Normalization of tumor vessels by Tie2 activation and Ang2 inhibition enhances drug delivery and produces a favorable tumor microenvironment, Cancer Cell, 2016

•Inference of brain pathway activities for Alzheimer's disease classification, BMC Medical Informatics and Decision Making, 2015

Healthcare Informatics

National Library of Medicine (NLM) defines healthcare informatics as the interdisciplinary study of the design, development, adoption, and application of IT-based innovations in healthcare service delivery, management, and planning. BISL is applying deep learning, information visualization, blockchain and crowdsourcing techniques for future healthcare information systems.

•Deep learning classification of physical activity with improved time resolution for children, PeerJ, 2018

•CORUS: a blockchain-based trustworthy evaluation system for efficacy of healthcare remedies, CloudCom 2018, 2018

•Discovering health benefits of phytochemicals with integrated analysis of molecular network, chemical properties and ethnopharmacological evidence, Nutrients, 2018

•Differential activation of immune/inflammatory response related co-expression modules in the hippocampus across major psychiatric disorders, Molecular Psychiatry, 2015

•Somatic deletions implicated in functional diversity of brain cells of individuals with schizophrenia and unaffected controls, Scientific Reports, 2014